Cell (biology) Totally Explained

Everything about Cell Biology totally explained

The cell is the structural and functional unit of all known living organisms. It is the smallest unit of an organism that's classified as living, and is sometimes called the building block of life. Some organisms, such as most bacteria, are unicellular (consist of a single cell). Other organisms, such as humans, are multicellular. (Humans have an estimated 100 trillion or 10¹⁴ cells; a typical cell size is 10 µm; a typical cell mass is 1 nanogram.) The largest known cell is an ostrich egg. In 1837 before the final cell theory was developed, a Czech Jan Evangelista Purkyně observed small "granules" while looking at the plant tissue through a microscope. The cell theory, first developed in 1839 by Matthias Jakob Schleiden and Theodor Schwann, states that all organisms are composed of one or more cells. All cells come from preexisting cells. Vital functions of an organism occur within cells, and all cells contain the hereditary information necessary for regulating cell functions and for transmitting information to the next generation of cells.
The word cell comes from the Latin cellula, meaning, a small room. The descriptive name for the smallest living biological structure was chosen by Robert Hooke in a book he published in 1665 when he compared the cork cells he saw through his microscope to the small rooms monks lived in.

Preamble

Each cell is at least somewhat self-contained and self-maintaining: it can take in nutrients, convert these nutrients into energy, carry out specialized functions, and reproduce as necessary. Each cell stores its own set of instructions for carrying out each of these activities. All cells have several different abilities:

Reproduction by cell division: (binary fission/mitosis or meiosis).
Use of enzymes and other proteins coded for by DNA genes and made via messenger RNA intermediates and ribosomes.
Metabolism, including taking in raw materials, building cell components, converting energy, molecules and releasing by-products. The functioning of a cell depends upon its ability to extract and use chemical energy stored in organic molecules. This energy is released and then used in metabolic pathways.
Response to external and internal stimuli such as changes in temperature, pH or levels of nutrients.
Cell contents are contained within a cell surface membrane that's made from a lipid bilayer with proteins embedded in it.

Some prokaryotic cells contain important internal membrane-bound compartments, but eukaryotic cells have a specialized set of internal membrane compartments. Material is moved between these compartments by regulated traffic and transport of small spheres of membrane-bound material called vesicles.

Anatomy of cells

There are two types of cells: eukaryotic and prokaryotic. Prokaryotic cells are usually independent, while eukaryotic cells are often found in multicellular organisms.

Prokaryotic cells

Prokaryotes differ from eukaryotes since they lack a nuclear membrane and a cell nucleus. Prokaryotes also lack most of the intracellular organelles and structures that are seen in eukaryotic cells. There are two kinds of prokaryotes, bacteria and archaea, but these are similar in the overall structures of their cells. Most functions of organelles, such as mitochondria, chloroplasts, and the Golgi apparatus, are taken over by the prokaryotic cell's plasma membrane. Prokaryotic cells have three architectural regions: appendages called flagella and pili — proteins attached to the cell surface; a cell envelope - consisting of a capsule, a cell wall, and a plasma membrane; and a cytoplasmic region that contains the cell genome (DNA) and ribosomes and various sorts of inclusions. Other differences include:

The plasma membrane (a phospholipid bilayer) separates the interior of the cell from its environment and serves as a filter and communications beacon.

Most prokaryotes have a cell wall (some exceptions are Mycoplasma (bacteria) and Thermoplasma (archaea)). This wall consists of peptidoglycan in bacteria, and acts as an additional barrier against exterior forces. It also prevents the cell from "exploding" (cytolysis) from osmotic pressure against a hypotonic environment. A cell wall is also present in some eukaryotes like plants (cellulose) and fungi, but has a different chemical composition.

A prokaryotic chromosome is usually a circular molecule (an exception is that of the bacterium Borrelia burgdorferi, which causes Lyme disease). Even without a real nucleus, the DNA is condensed in a nucleoid. Prokaryotes can carry extrachromosomal DNA elements called plasmids, which are usually circular. Plasmids can carry additional functions, such as antibiotic resistance.

Eukaryotic cells

Eukaryotic cells are about 10 times the size of a typical prokaryote and can be as much as 1000 times greater in volume. The major difference between prokaryotes and eukaryotes is that eukaryotic cells contain membrane-bound compartments in which specific metabolic activities take place. Most important among these is the presence of a cell nucleus, a membrane-delineated compartment that houses the eukaryotic cell's DNA. It is this nucleus that gives the eukaryote its name, which means "true nucleus." Other differences include:

The plasma membrane resembles that of prokaryotes in function, with minor differences in the setup. Cell walls may or may not be present.

The eukaryotic DNA is organized in one or more linear molecules, called chromosomes, which are associated with histone proteins. All chromosomal DNA is stored in the cell nucleus, separated from the cytoplasm by a membrane. Some eukaryotic organelles also contain some DNA.

Eukaryotes can move using cilia or flagella. The flagella are more complex than those of prokaryotes. Table 1: Comparison of features of prokaryotic and eukaryotic cells>

	Prokaryotes	Eukaryotes
Typical organisms	bacteria, archaea	protists, fungi, plants, animals
Typical size	~ 1-10 µm	~ 10-100 µm (sperm cells, apart from the tail, are smaller)
Type of nucleus	nucleoid region; no real nucleus	real nucleus with double membrane
DNA	circular (usually)	linear molecules (chromosomes) with histone proteins
RNA-/protein-synthesis	coupled in cytoplasm	RNA-synthesis inside the nucleus protein synthesis in cytoplasm
Ribosomes	50S+30S	60S+40S
Cytoplasmatic structure	very few structures	highly structured by endomembranes and a cytoskeleton
Cell movement	flagella made of flagellin	flagella and cilia made of tubulin, lamellipodia
Mitochondria	none	one to several thousand (though some lack mitochondria)
Chloroplasts	none	in algae and plants
Organization	usually single cells	single cells, colonies, higher multicellular organisms with specialized cells
Cell division	Binary fission (simple division)	Mitosis (fission or budding) Meiosis

Table 2: Comparison of structures between animal and plant cells>

	Typical animal cell	Typical plant cell
Organelles	Nucleus Nucleolus (within nucleus) Rough endoplasmic reticulum (ER) Smooth ER Ribosomes Cytoskeleton Golgi apparatus Cytoplasm Mitochondria Vesicles Lysosomes Centrosome Centrioles Vacuoles	Nucleus Nucleolus (within nucleus) Rough ER Smooth ER Ribosomes Cytoskeleton Golgi apparatus (dictiosomes) Cytoplasm Mitochondria Vesicles Chloroplast and other plastids Central vacuole(large) Tonoplast (central vacuole membrane) Peroxisome (for example Glyoxysome) Vacuoles
Additional structures	Plasma membrane Flagellum Cilium	Plasma membrane Flagellum (only in gametes) Cell wall Plasmodesmata

Subcellular components

All cells, whether prokaryotic or eukaryotic, have a membrane that envelops the cell, separates its interior from its environment, regulates what moves in and out (selectively permeable), and maintains the electric potential of the cell. Inside the membrane, a salty cytoplasm takes up most of the cell volume. All cells possess DNA, the hereditary material of genes, and RNA, containing the information necessary to build various proteins such as enzymes, the cell's primary machinery. There are also other kinds of biomolecules in cells. This article will list these primary components of the cell, then briefly describe their function.

Cell membrane: A cell's defining boundary

The cytoplasm of a cell is surrounded by a plasma membrane. The plasma membrane in plants and prokaryotes is usually covered by a cell wall. This membrane serves to separate and protect a cell from its surrounding environment and is made mostly from a double layer of lipids (hydrophobic fat-like molecules) and hydrophilic phosphorus molecules. Hence, the layer is called a phospholipid bilayer. It may also be called a fluid mosaic membrane. Embedded within this membrane is a variety of protein molecules that act as channels and pumps that move different molecules into and out of the cell. The membrane is said to be 'semi-permeable', in that it can either let a substance (molecule or ion) pass through freely, pass through to a limited extent or not pass through at all. Cell surface membranes also contain receptor proteins that allow cells to detect external signalling molecules such as hormones.

Cytoskeleton: A cell's scaffold

The cytoskeleton acts to organize and maintain the cell's shape; anchors organelles in place; helps during endocytosis, the uptake of external materials by a cell, and cytokinesis, the separation of daughter cells after cell division; and moves parts of the cell in processes of growth and mobility. The eukaryotic cytoskeleton is composed of microfilaments, intermediate filaments and microtubules. There is a great number of proteins associated with them, each controlling a cell's structure by directing, bundling, and aligning filaments. The prokaryotic cytoskeleton is less well-studied but is involved in the maintenance of cell shape, polarity and cytokinesis.

Genetic material

Two different kinds of genetic material exist: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). Most organisms use DNA for their long-term information storage, but some viruses (for example, retroviruses) have RNA as their genetic material. The biological information contained in an organism is encoded in its DNA or RNA sequence. RNA is also used for information transport (for example, mRNA) and enzymatic functions (for example, ribosomal RNA) in organisms that use DNA for the genetic code itself.
   Prokaryotic genetic material is organized in a simple circular DNA molecule (the bacterial chromosome) in the nucleoid region of the cytoplasm. Eukaryotic genetic material is divided into different, linear molecules called chromosomes inside a discrete nucleus, usually with additional genetic material in some organelles like mitochondria and chloroplasts (see endosymbiotic theory).
   A human cell has genetic material in the nucleus (the nuclear genome) and in the mitochondria (the mitochondrial genome). In humans the nuclear genome is divided into 46 linear DNA molecules called chromosomes. The mitochondrial genome is a circular DNA molecule separate from the nuclear DNA. Although the mitochondrial genome is very small, it codes for some important proteins.
   Foreign genetic material (most commonly DNA) can also be artificially introduced into the cell by a process called transfection. This can be transient, if the DNA isn't inserted into the cell's genome, or stable, if it is.

Organelles

The human body contains many different organs, such as the heart, lung, and kidney, with each organ performing a different function. Cells also have a set of "little organs," called organelles, that are adapted and/or specialized for carrying out one or more vital functions. Membrane-bound organelles are found only in eukaryotes.

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